Quarterfinals (Through first legs)
- Olimpia 2-1 Montreal Impact
- America 3-0 Atlanta United
- UANL 1-0 New York City
- Cruz Azul – LAFC; First leg has not been played
Round of 16
- Montreal Impact 2-2 Saprissa; Montreal advances on away goals
- Olimpia 4(4)-4(2) Seattle Sounders; Olimpia advances on penalty kicks
- New York City 6-3 San Carlos
- UANL 5-4 Alianza
- LAFC 3-2 Leon
- Cruz Azul 6-1 Portmore United
- America 2(5)-2(3) Comunicaciones; America advances on penalty kicks
- Atlanta United 4-1 Motagua