Group A
Orlando City 3-1 New York City FC
Philadelphia Union 2-1 Inter Miami
Table
- Orlando- 2 GP, 6 Pts (Will advance to Rd of 16)
- Philadelphia- 2 GP, 6 Pts (Will advance to Rd of 16)
- Miami- 2 GP, 0 Pts
- NYCFC- 2 GP, 0 Pts
Group B
Chicago Fire 2-1 Seattle Sounders
Table
- Chicago- 1 GP, 3 Pts
- San Jose- 1 GP, 1 Pt
- Seattle- 2 GP, 1 Pt
- Vancouver- 0 GP, 0 Pts